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Dr. Amr Abdel Monem M.D.
Faculty of Medicine Cairo University
Prof. of anesthesia and clinical nutrition
Member of NAASO & ASRA

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Obesity and Science
Are you obese?
Biological issues
Metabolic syndrome
Sleep and obesity
Obesity and fatty liver
Obesity and diseases of civilization
Spot reduction is mentioned to be condemned
Obesity management
The golden rule is weight
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 :: Obesity and Diseases of Civilization

Obesity and Hypertension:

Data from national health and nutrition examination survey (NHANES III) show that the (age – adjusted prevalence) Of high blood pressure increases progressively with higher levels Of BMI in men and women and the mechanism lies behind the path physiology of obesity namely hyperinsulinemia and insulin resistance that result in Increased sodium retention, Increased sympathetic nervous system activity and Alteration in the mechanics of blood vessels.

Obesity and Coronary Artery Disease:

Observational studies have shown that central (abdominal )obesity is directly related to cardiovascular risk factors (increased cholesterol , increased LDL, increased triglycerides, hypertension, increased fibrinogen,hyperinsulinemia , decreased HDL, and increased plasminogen activator inhibitor).

Obesity and Type II Diabetes:

It represents 90% of all cases of diabetes, and it requires years of underlying metabolic disturbance before symptoms become apparent. The development and diagnosis usually follows weight gain.

In Type I and Type II diabetes blood sugar is elevated but for different reasons: Type I there is no insulin to hold it down by moving it into cells, whereas in Type II the cells become resistant to insulin that even large amounts can’t adequately move the sugar into cells. In early stages there is hyperinsulinemia; later pancreatic beta cells wear out from constantly producing insulin under stimulation of hyperglycemia (Liese et al, Eur J Nutr.2001; 40:282).

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